Fifteen-year-old Regan's life, which has always revolved around keeping her older brother Liam's transsexuality a secret, changes when Liam decides to start the process of "transitioning" by first telling his family and friends that he is a girl who was born in a boy's body.

When Alix's charismatic girlfriend, Swanee, dies from sudden cardiac arrest, Alix is overcome with despair. As she searches Swanee's room for mementos of their relationship, she finds Swanee's cell phone, pinging with dozens of texts sent from a mysterious contact, L.T. The most recent text reads: "Please tell me what I did. Please, Swan. Te amo. I love you."Shocked and betrayed, Alix learns that Swanee has been leading a double life--secretly dating...

Earl and Damian jeopardize their friendship when they compete in a contest to see who has the smelliest sneakers.

Fourteen-year-old Nick has a three-legged dog named Lucky 2, some pet fish, and two mothers, whose relationship complicates his entire life as they face prejudice, work problems, alcoholism, cancer, and finally separation.